Caffeine and Arrhythmias

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Coffee, caffeine, and risk of hospitalization for arrhythmias.

CONTEXT Population study data about relations of coffee drinking to arrhythmia are sparse. OBJECTIVE To study relations of coffee drinking to risk of cardiac arrhythmia in 130,054 persons with previous data about coffee habits.Design and Outcome Measure: We used Cox proportional hazards models with 8 covariates to study coffee-related risk in 3137 persons hospitalized for cardiac arrhythmia. ...

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Caffeine and cardiac arrhythmias: a review of the evidence.

Limited data exist on the safety and physiologic effects of caffeine in patients with known arrhythmias. The studies presented suggest that in most patients with known or suspected arrhythmia, caffeine in moderate doses is well tolerated and there is therefore no reason to restrict ingestion of caffeine. A review of the literature is presented.

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Ryanodine and caffeine prevent ventricular arrhythmias during acute myocardial ischemia and reperfusion in rat heart.

This study investigates the possible role of oscillatory release of calcium from sarcoplasmic reticulum in the genesis of ventricular arrhythmias during acute myocardial ischemia and reperfusion in isolated rat hearts. We used ryanodine and caffeine, which are known to modulate the oscillatory release of calcium from sarcoplasmic reticulum. During 30 minutes of left main coronary artery ligatio...

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Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis.

Heart failure leading to ventricular arrhythmogenesis is a major cause of clinical mortality and has been associated with a leak of sarcoplasmic reticular Ca(2+) into the cytosol due to increased open probabilities in cardiac ryanodine receptor Ca(2+)-release channels. Caffeine similarly increases such open probabilities, and so we explored its arrhythmogenic effects on intact murine hearts. A ...

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Caffeine-induced Arrhythmias in Murine Hearts Parallel Changes in Cellular Ca Homeostasis

Heart failure leading to ventricular arrhythmogenesis is a major cause of clinical mortality and has been associated with a leak of sarcoplasmic reticular (SR) Ca 2+ into the cytosol due to increased open probabilities in cardiac ryanodine receptor (RyR2)-Ca 2+ release channels. Caffeine similarly increases such open probabilities and so we explored its arrhythmogenic effects in intact murine h...

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ژورنال

عنوان ژورنال: JACC: Clinical Electrophysiology

سال: 2018

ISSN: 2405-500X

DOI: 10.1016/j.jacep.2018.01.012